Comparative animal pathology core and tissue cohort outreach
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PD Dr. med. vet. Katja Steiger
Technical University of Munich
Institute of Pathology(link is external)
Core Facility Comparative Experimental Pathology(link is external)
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Prof. Dr. med. Wilko Weichert
Technical University of Munich
Institute of Pathology(link is external)
Project Summary
Z01 provides an already established and fully equipped morphomolecular comparative experimental pathology platform aiming at cutting-edge animal phenotyping supplemented by a comparative human tissue cohort outreach for the assessment of the complex roles of aberrant intrinsic and extrinsic immune cell signaling in cancer. Thus, this central project will support all subprojects in the implementation of translational tissue-based morphomolecular analyses of (pre-)neoplastic cells and immune cells into their research programs, which will greatly facilitate the valid interpretation of genotype-phenotype correlations.
Thiele Orberg, E., Meedt, E., Hiergeist, A., Xue, J., Heinrich, P., Ru, J., Ghimire, S., Miltiadous, O., Lindner, S., Tiefgraber, M., Goldel, S., Eismann, T., Schwarz, A., Gottert, S., Jarosch, S., Steiger, K., Schulz, C., Gigl, M., Fischer, J.C., Janssen, K.P., Quante, M., Heidegger, S., Herhaus, P., Verbeek, M., Ruland, J., van den Brink, M.R.M., Weber, D., Edinger, M., Wolff, D., Busch, D.H., Kleigrewe, K., Herr, W., Bassermann, F., Gessner, A., Deng, L., Holler, E., Poeck, H. (2024). Nat Cancer.
DOI:10.1038/s43018-023-00669-x(link is external)
Wahida, A., Schmaderer, C., Buttner-Herold, M., Branca, C., Donakonda, S., Haberfellner, F., Torrez, C., Schmitz, J., Schulze, T., Seibt, T., Ollinger, R., Engleitner, T., Haller, B., Steiger, K., Gunthner, R., Lorenz, G., Yabal, M., Bachmann, Q., Braunisch, M.C., Moog, P., Matevossian, E., Assfalg, V., Thorban, S., Renders, L., Spath, M.R., Muller, R.U., Stippel, D.L., Weichert, W., Slotta-Huspenina, J., von Vietinghoff, S., Viklicky, O., Green, D.R., Rad, R., Amann, K., Linkermann, A., Brasen, J.H., Heemann, U., Kemmner, S. (2023). iScience 26, 107879.
DOI:10.1016/j.isci.2023.107879(link is external)
Wahida, A., Schmaderer, C., Buttner-Herold, M., Branca, C., Donakonda, S., Haberfellner, F., Torrez, C., Schmitz, J., Schulze, T., Seibt, T., Ollinger, R., Engleitner, T., Haller, B., Steiger, K., Gunthner, R., Lorenz, G., Yabal, M., Bachmann, Q., Braunisch, M.C., Moog, P., Matevossian, E., Assfalg, V., Thorban, S., Renders, L., Spath, M.R., Muller, R.U., Stippel, D.L., Weichert, W., Slotta-Huspenina, J., von Vietinghoff, S., Viklicky, O., Green, D.R., Rad, R., Amann, K., Linkermann, A., Brasen, J.H., Heemann, U., Kemmner, S. (2023). iScience 26, 107879.
DOI:10.1016/j.isci.2023.107879(link is external)
Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., Zizmare, L., Sarusi-Portuguez, A., Gupta, R., O'Connor, T., Giannou, A. D., Shiri, A. M., Schlesinger, Y., Beccaria, M. G., Rennert, C., Pfister, D., Öllinger, R., Gadjalova, I., Ramadori, P., Rahbari, M., Rahbari, N., Healy, M. E., Fernández-Vaquero, M., Yahoo, N., Janzen, J., Singh, I., Fan, C., Liu, X., Rau, M., Feuchtenberger, M., Schwaneck, E., Wallace, S. J., Cockell, S., Wilson-Kanamori, J., Ramachandran, P., Kho, C., Kendall, T. J., Leblond, A. L., Keppler, S. J., Bielecki, P., Steiger, K., Hofmann, M., Rippe, K., Zitzelsberger, H., Weber, A., Malek, N., Luedde, T., Vucur, M., Augustin, H. G., Flavell, R., Parnas, O., Rad, R., Pabst, O., Henderson, N. C., Huber, S., Macpherson, A., Knolle, P., Claassen, M., Geier, A., Trautwein, C., Unger, K., Elinav, E., Waisman, A., Abdullah, Z., Haller, D., Tacke, F., Anstee, Q. M. & Heikenwalder, M. (2023). J Hepatol, 79, 296-313.
DOI:10.1016/j.jhep.2023.04.037(link is external)
Morrish, E., Wartewig, T., Kratzert, A., Rosenbaum, M., Steiger, K. & Ruland, J. (2022). Eur J Immunol, e2250147.
DOI:10.1002/eji.202250147(link is external)
Tulessin, M., Sarker, R.S.J., Griger, J., Leibing, T., Geraud, C., Weichert, W., Steiger, K., Mogler, C. (2022). Cells 11.
DOI:10.3390/cells11142129(link is external)
Foersch, S., Lang-Schwarz, C., Eckstein, M., Geppert, C., Schmitt, M., Konukiewitz, B., Groll, T., Schicktanz, F., Engel, J., Gleitsmann, M., Westhoff, C.C., Frickel, N., Litmeyer, A.S., Grass, A., Jank, P., Lange, S., Tschurtschenthaler, M., Wilhelm, D., Roth, W., Vieth, M., Denkert, C., Nagtegaal, I., Weichert, W., Jesinghaus, M. (2022). Br J Cancer.
DOI:10.1038/s41416-022-01889-1(link is external)
Maisam Afzali, A., Stuve, L., Pfaller, M., Aly, L., Steiger, K., Knier, B., Korn, T. (2022). J Mol Med (Berl).
DOI:10.1007/s00109-022-02202-6(link is external)
Groll, T., Silva, M., Sarker, R.S.J., Tschurtschenthaler, M., Schnalzger, T., Mogler, C., Denk, D., Scholch, S., Schraml, B.U., Ruland, J., Rad, R., Saur, D., Weichert, W., Jesinghaus, M., Matiasek, K., Steiger, K. (2022). Cancers (Basel) 14.
DOI:10.3390/cancers14092248 (link is external)
Seitz, S., Dreyer, T.F., Stange, C., Steiger, K., Brauer, R., Scheutz, L., Multhoff, G., Weichert, W., Kiechle, M., Magdolen, V., Bronger, H. (2022). Br J Cancer.
DOI:10.1038/s41416-022-01763-0(link is external)
Kerle, I.A., Jägerhuber, L., Secci, R., Pfarr, N., Blüm, P., Roesch, R., Götze, K.S., Weichert, W., Bassermann, F., Ruland, J., Winter, C. (2022). Cancers 14.
DOI:10.3390/cancers14061371(link is external)
Conrad, D., Kehl, A., Beitzinger, C., Metzler, T., Steiger, K., Pfarr, N., Fischer, K., Klopfleisch, R., Aupperle-Lellbach, H. (2022). Vet Sci 9.
DOI:10.3390/vetsci9020056(link is external)
Meinhardt, A.L., Munkhbaatar, E., Hockendorf, U., Dietzen, M., Dechant, M., Anton, M., Jacob, A., Steiger, K., Weichert, W., Brcic, L., McGranahan, N., Branca, C., Kaufmann, T., Dengler, M.A., Jost, P.J. (2022). Oncogene
DOI:10.1038/s41388-021-02161-1(link is external)
Herz, A.L., Wisser, S., Kohlruss, M., Slotta-Huspenina, J., Jesinghaus, M., Grosser, B., Steiger, K., Novotny, A., Hapfelmeier, A., Schmidt, T., Gaida, M.M., Weichert, W., Keller, G. (2022). J Pathol Clin Res.
DOI:10.1002/cjp2.257(link is external)
Schick, M., Zhang, L., Maurer, S., Maurer, H.C., Isaakaidis, K., Schneider, L., Patra, U., Schunck, K., Rohleder, E., Hofstetter, J., Baluapuri, A., Scherger, A.K., Slotta-Huspenina, J., Hettler, F., Weber, J., Engleitner, T., Maresch, R., Slawska, J., Lewis, R., Istvanffy, R., Habringer, S., Steiger, K., Baiker, A., Oostendorp, R.A.J., Miething, C., Lenhof, H.P., Bassermann, F., Chapuy, B., Wirth, M., Wolf, E., Rad, R., Muller, S., Keller, U. (2022). Nat Commun 13, 281.
DOI:10.1038/s41467-021-27704-8(link is external)
Kurgyis, Z., Vornholz, L., Pechloff, K., Kemeny, L.V., Wartewig, T., Muschaweckh, A., Joshi, A., Kranen, K., Hartjes, L., Mockel, S., Steiger, K., Hameister, E., Volz, T., Mellett, M., French, L.E., Biedermann, T., Korn, T., Ruland, J. (2021). Sci Immunol 6, eabi4425.
DOI:10.1126/sciimmunol.abi4425(link is external)
Konukiewitz, B., Kasajima, A., Schmitt, M., Schwamborn, K., Groll, T., Schicktanz, F., Delbridge, C., Schutze, L.M., Wilhelm, D., Lang, C., Lange, S., Foersch, S., Jank, P., Steiger, K., Werder, A.V., Denkert, C., Weichert, W., Kloppel, G., Jesinghaus, M. (2021). Cancers (Basel) 13.
DOI:10.3390/cancers13205111(link is external)
Schmitt, M., Silva, M., Konukiewitz, B., Lang, C., Steiger, K., Halfter, K., Engel, J., Jank, P., Pfarr, N., Wilhelm, D., Foersch, S., Denkert, C., Tschurtschenthaler, M., Weichert, W., Jesinghaus, M. (2021). Cancers 13.
DOI:10.3390/cancers13246177(link is external)
Wahida, A., Muller, M., Hiergeist, A., Popper, B., Steiger, K., Branca, C., Tschurtschenthaler, M., Engleitner, T., Donakonda, S., De Coninck, J., Ollinger, R., Pfautsch, M.K., Muller, N., Silva, M., Usluer, S., Thiele Orberg, E., Bottcher, J.P., Pfarr, N., Anton, M., Slotta-Huspenina, J.B., Nerlich, A.G., Madl, T., Basic, M., Bleich, A., Berx, G., Ruland, J., Knolle, P.A., Rad, R., Adolph, T.E., Vandenabeele, P., Kanegane, H., Gessner, A., Jost, P.J., Yabal, M. (2021). Sci Immunol 6, eabf7235.
DOI:10.1126/sciimmunol.abf7235(link is external)
Konukiewitz, B., Schmitt, M., Silva, M., Pohl, J., Lang, C., Steiger, K., Halfter, K., Engel, J., Schlitter, A.M., Boxberg, M., Pfarr, N., Wilhelm, D., Foersch, S., Tschurtschenthaler, M., Weichert, W., Jesinghaus, M. (2021). Br J Cancer.
DOI:10.1038/s41416-021-01553-0(link is external)
Salei, N., Ji, X., Pakalniskyte, D., Kuentzel, V., Rambichler, S., Li, N., Moser, M., Steiger, K., Buch, T., Anders, H.J., Schraml, B.U. (2021). Proc Natl Acad Sci U S A 118.
DOI:10.1073/pnas.2022311118(link is external)
Lewis, R., Maurer, H. C., Singh, N., Gonzalez-Menendez, I., Wirth, M., Schick, M., Zhang, L., Isaakidis, K., Scherger, A. K., Schulze, V., Lu, J., Zenz, T., Steiger, K., Rad, R., Quintanilla-Martinez, L., Espeli, M., Balabanian, K., Keller, U., Habringer, S. (2021). Leukemia.
DOI:10.1038/s41375-021-01376-1(link is external)
Jesinghaus, M., Schmitt, M., Lang, C., Reiser, M., Scheiter, A., Konukiewitz, B., Steiger, K., Silva, M., Tschurtschenthaler, M., Lange, S., Foersch, S., Becker, K. F., Saur, D., Friess, H., Halfter, K., Engel, J., Boxberg, M., Pfarr, N., Wilhelm, D., Weichert, W. (2021). Am J Surg Pathol 45, 969-978.
DOI:10.1097/PAS.0000000000001692(link is external)
Dreyer, T. F., Kuhn, S., Stange, C., Heithorst, N., Schilling, D., Jelsma, J., Sievert, W., Seitz, S., Stangl, S., Hapfelmeier, A., Noske, A., Wege, A. K., Weichert, W., Ruland, J., Schmitt, M., Dorn, J., Kiechle, M., Reuning, U., Magdolen, V., Multhoff, G., Bronger, H. (2021). Cancer Immunol Res 9, 779-789.
DOI:10.1158/2326-6066.CIR-20-0327(link is external)
Ecker, V., Stumpf, M., Brandmeier, L., Neumayer, T., Pfeuffer, L., Engleitner, T., Ringshausen, I., Nelson, N., Jucker, M., Wanninger, S., Zenz, T., Wendtner, C., Manske, K., Steiger, K., Rad, R., Muschen, M., Ruland, J., Buchner, M. (2021). Nat Commun 12, 3526.
DOI:10.1038/s41467-021-23752-2(link is external)
Alankus, B., Ecker, V., Vahl, N., Braun, M., Weichert, W., Macher-Goppinger, S., Gehring, T., Neumayer, T., Zenz, T., Buchner, M., Ruland, J. (2021). J Exp Med 218.
DOI:10.1084/jem.20200517(link is external)
Munkhbaatar, E., Dietzen, M., Agrawal, D., Anton, M., Jesinghaus, M., Boxberg, M., Pfarr, N., Bidola, P., Uhrig, S., Hockendorf, U., Meinhardt, A. L., Wahida, A., Heid, I., Braren, R., Mishra, R., Warth, A., Muley, T., Poh, P. S. P., Wang, X., Frohling, S., Steiger, K., Slotta-Huspenina, J., van Griensven, M., Pfeiffer, F., Lange, S., Rad, R., Spella, M., Stathopoulos, G. T., Ruland, J., Bassermann, F., Weichert, W., Strasser, A., Branca, C., Heikenwalder, M., Swanton, C., McGranahan, N., Jost, P. J. (2020). Nat Commun 11, 4527.
DOI:10.1038/s41467-020-18372-1(link is external)
Steiger, K., Gross, N., Widholz, S. A., Rad, R., Weichert, W., Mogler, C. (2020). Cancers (Basel) 12.
DOI:10.3390/cancers12082265(link is external)
Biederstadt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H. P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Muller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. (2020). Gut 69, 1472-1482.
DOI:10.1136/gutjnl-2018-317856(link is external)
Heidegger, S., Wintges, A., Stritzke, F., Bek, S., Steiger, K., Koenig, P. A., Gottert, S., Engleitner, T., Ollinger, R., Nedelko, T., Fischer, J. C., Makarov, V., Winter, C., Rad, R., van den Brink, M. R. M., Ruland, J., Bassermann, F., Chan, T. A., Haas, T., Poeck, H. (2019). Sci Immunol 4.
DOI:10.1126/sciimmunol.aau8943(link is external)
Schug, C., Kitzberger, C., Sievert, W., Spellerberg, R., Tutter, M., Schmohl, K. A., Eberlein, B., Biedermann, T., Steiger, K., Zach, C., Schwaiger, M., Multhoff, G., Wagner, E., Nelson, P. J., Spitzweg, C. (2019). Clin Cancer Res 25, 5997-6008.
DOI:10.1158/1078-0432.Ccr-18-4092(link is external)
Scherger, A.K., Al-Maarri, M., Maurer, H.C., Schick, M., Maurer, S., Ollinger, R., Gonzalez-Menendez, I., Martella, M., Thaler, M., Pechloff, K., Steiger, K., Sander, S., Ruland, J., Rad, R., Quintanilla-Martinez, L., Wunderlich, F.T., Rose-John, S., Keller, U. (2019). JCI Insight 4.
DOI: 10.1172/jci.insight.128435(link is external)
Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H.E., Roelli, P., Utzschneider, D.T., von Hoesslin, M., Cullen, J.G., Fan, Y., Eisenberg, V., Wohlleber, D., Steiger, K., Merkler, D., Delorenzi, M., Knolle, P.A., Cohen, C.J., Thimme, R., Youngblood, B., Zehn, D. (2019). Nature 571, 265-269.
DOI: 10.1038/s41586-019-1326-9(link is external)
Rosenbaum, M., Gewies, A., Pechloff, K., Heuser, C., Engleitner, T., Gehring, T., Hartjes, L., Krebs, S., Krappmann, D., Kriegsmann, M., Weichert, W., Rad, R., Kurts, C., Ruland, J. (2019). Nat Commun 10, 2352.
DOI: 10.1038/s41467-019-10203-2(link is external)
Albers, J.J., Ammon, T., Gosmann, D., Audehm, S., Thoene, S., Winter, C., Secci, R., Wolf, A., Stelzl, A., Steiger, K., Ruland, J., Bassermann, F., Kupatt, C., Anton, M., Krackhardt, A.M. (2019). Life Sci Alliance 2.
DOI: 10.26508/lsa.201900367(link is external)
Weber, J., de la Rosa, J., Grove, C.S., Schick, M., Rad, L., Baranov, O., Strong, A., Pfaus, A., Friedrich, M.J., Engleitner, T., Lersch, R., Ollinger, R., Grau, M., Menendez, I.G., Martella, M., Kohlhofer, U., Banerjee, R., Turchaninova, M.A., Scherger, A., Hoffman, G.J., Hess, J., Kuhn, L.B., Ammon, T., Kim, J., Schneider, G., Unger, K., Zimber-Strobl, U., Heikenwalder, M., Schmidt-Supprian, M., Yang, F., Saur, D., Liu, P., Steiger, K., Chudakov, D.M., Lenz, G., Quintanilla-Martinez, L., Keller, U., Vassiliou, G.S., Cadinanos, J., Bradley, A., Rad, R. (2019). Nat Commun 10, 1415.
DOI: 10.1038/s41467-019-09180-3(link is external)