Mechanisms of immune evasion caused by aberrant innate nucleic acid receptor signaling in tumor cells and their tumor microenvironment
Prof. Dr. med. Hendrik Poeck
University Hospital Regensburg
Clinic and Polyclinic for internal medicine III, Hematology and Oncology(link is external)
Project Summary
Type I interferons (IFN-I) induced by innate immune signaling pathways in immune and tumor cells are emerging as intriguing determinants of both anti-melanoma responses as well as immune escape and resistance mechanisms. In this proposal, we aim to understand the distinct contribution of IFN-I inducing nucleic acid receptor pathways in tumor and host cells during development and immunosurveillance of melanoma as well as to identify the mechanisms that drive disease resistance.
The scientific work of Professor Dr. Hendrik Poeck, Senior Physician in charge of the Clinic and Polyclinic for Internal Medicine III of the University Hospital Regensburg (UKR), is funded as part of the newly established excellence program of the German Cancer Aid (DKH).
The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients.
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DOI:10.1002/eji.202049158(link is external)
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DOI: 10.1016/j.ebiom.2019.02.056(link is external)
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DOI: 10.1002/eji.201847818(link is external)
Bek, S., Stritzke, F., Wintges A., Nedelko, T., Böhmer, D.F.R., Fischer, J.C., Haas, T., Poeck, H., Heidegger, S. (2019). OncoImmunology 8, e1570779.
DOI: 10.1080/2162402X.2019.1570779(link is external)