Aberrant T cell receptor signaling pathways in lymphoma
Prof. Dr. med. Jürgen Ruland
Technical University of Munich
School of Medicine
Institute of Clinical Chemistry and Pathobiochemistry(link is external)
TranslaTUM(link is external)
Project Summary
The aberrant activation of antigen receptor signaling is frequently observed in lymphoma, but whether these activities are sufficient for lymphomagenesis remains unclear. We previously demonstrated that expression of the fusion protein ITK-SYK mimics qualitative aspects of a constitutively active T cell receptor (TCR) signal in vitro and that conditional ITK-SYK transgenic mice develop PTCL with 100% penetrance. Here, we want to understand whether ITK-SYK-driven lymphomas depend on additional signaling input via the TCR, how acute ITK-SYK signaling is initially counter-regulated in non-transformed T cells and which lymphomagenic events finally disrupt such tumor suppressive pathways.
A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells.
Image: Andreas Heddergott / TUM
The professor of clinical chemistry is honored for his outstanding scientific work in the field of immunology, as announced by the German Research Foundation (DFG)
The European Research Council (ERC) is funding a project by Prof. Dr. Jürgen Ruland with a renowned Advanced Grant.
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